112 Tran Hung Dao St, Pham Ngu Lao Ward, District 1, HCMC | Tel: 028.3836.0505 - Fax: 028.3836.0111
FIRST WE ARE THE BEST
THEN WE ARE THE FIRST

AMLOBOSTON 5

COMPOSITION:
Each capsule contains:
Active ingredient: Amlodipine besylate equivalent to amoldipine 5 mg
Excipients: Avicel, Maize starch, Magnesium stearate q.s for 1 capsule

 

Rx PRESCRIPTION ONLY MEDICINE
COMPOSITION:

Each capsule contains:
Active ingredient: Amlodipine besylate equivalent to amoldipine 5 mg
Excipients: Avicel, Maize starch, Magnesium stearate q.s for 1 capsule.  
PHARMACODYNAMICS:
Amlodipine is a dihydropyridine which inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle.
The mechanism of the antihypertensive action of Amlodidpine is due to a direct relaxant effect on vascular smooth muscle of peripheral arteries that cause a reduction of renal vascular resistance, thus it increases renal plasma flow and improves renal function.
Amlodipine has not been associated with any adverse effects in plasma lipids and metabolic glucose. Thus, amlodipine is suitable for treatment hypertention in patients with diabetes. Due to the slow action thus the risk of acute hypotension or polycardia reflex are rare. It have good effect in the standing-supine-sitting positions and when working.
Amlodipine dilates the coronary arterioles, reduces peripheral resistance, reduces heart energy, reduces myocardial energy consumption and oxygen requirements thus amlodipine reduces the risk of angina pectoris. Amlodipine dilates also the main coronary arteries and arterioles both in normal and ischaemic regions. It increases myocardial oxygen delivery in patients with coronary artery spasm (Prinzmetal's or variant angina), thus decreases both nitroglycerine consumption and risk of nitroglycerine resistance. Antianginal effectiveness is maintained for 24 hours. In patients with angina, amlodipine may be used in combination with beta blockers and nitrate (basic treatment for angina pectoris).
PHARMACOKINETICS:
After oral doses, the bioavailability has been estimated to be from 60% to 80% and it is not altered by the presence of food. The peak plasma concentrations occurring after 6 to 12 hours after oral administration of therapeutic doses. Steady-state plasma concentrations are reached after 7 to 8 days of consecutive use once daily.
The volume of distribution is approximately 21 lit/kg, more 98% amlodipine bound to plasma protein.
The plasma elimination half-life is about 30 - 40 hours. Amlodipine is extensively metabolised in the liver; inactive metabolites are mostly excreted in urine. In patients with hepatic insufficiency, the biological half-life of amlodipine increases thus a reduced dose or prolonged interval between doses may be required.
INDICATIONS:
Hypertension (In patients having metabolism complications such as diabetics).
Prophylaxis of chronic stable angina pectoris.
DOSAGE AND ADMINISTRATION:
Administration: Oral route. No adjustment of the dose of amlodipine in case of concomitant administration with thiazide diuretics. If the dose is not effective after 4 weeks of therapy, it may be increased.
Dosage: Dosage should be adjusted according to patient's need as directed by the physician. The usual dose is 5 mg once daily. The dose may be increased to 10 mg once daily.  
CONTRAINDICATIONS:
Amlodipine should not be used in heart failure patients who are not yet treated stably.
Known hypersensitivity to any ingredient of the drug.
PRECAUTIONS:
Patients with impaired hepatic function.
Patients with aortic stenosis.
Patients with heart failure after myocardial infarction.
DRUG INTERACTIONS:
Anesthetics enhances the hypotension effect of amlodipine.
Concomitant use of lithium and amlodipine may cause nervous toxicity, nausea, diarrhoea.
Nonsteroidal anti-inflammatory drugs, particularly indomethacine may reduce the antihypertensive effect of amlodipine.
Caution should be taken when concomitant use of amlodipine and plasma-protein high-binding drugs (e.g. coumarine, hydantoine derivatives…) because amlodipine is also a protein high-binding drug and therefore the unbound concentration of the above drugs may be changed in the plasma.
ADVERSE EFFECTS:
The most common adverse effect of amlodipine is ankle oedema of mild to moderate depending on the used dose. This adverse effect occurs in about 3% and 11% of patients taking 5 mg amlodipine daily and 10 mg daily, respectively.
Common: ankle oedema, headache, vertigo, flushing, fatigue, asthenia,  palpitations, muscle cramps, dyspnoea, nausea,  dyspepsia…
Uncommon: excessive hypotension, tachycardia, chest pain, rash, pruritus, myalgia, arthralgia, disordered sleep...
Rare: extra systole, gingival hyperplasia, urticaria, hepatic enzyme elevation, hyperglycaemia, empty-headed, erythematous...
Notify your physicians if you should experience any of adverse effects
PREGNANCY AND LACTATION:
There are no report of amlodipine excretion in human milk.
EFFECTS ON ABILITY TO DRIVE AND USE MACHINES:
None.
OVERDOSAGE:
In human, experience with overdose of amolodipine is limited.
In case of amolodipine overdose, monitoring cardiac function, symptomatic treatment and gastric lavage should be necessary. If necessary, it should administer electrolytes. Patients with reduced circulating fluid volume should be given an infusion of sodium chloride 0.9%. If severe hypotension occurs, the patient should be given an intravenous injection of sodium chloride, adrenaline. Dialysis is not benefit.
STORAGE: In a dry place, below 30oC, protect from light.
SHELF-LIFE: 24 months from the date of manufacturing. Do not use after the expiry date.
PACKAGING: Box of 5 blisters x 10 capsules.
SPECIFICATIONS: Manufacturer’s specifications.
KEEP OUT OF REACH OF CHILDREN
USE ONLY AS DIRECTED BY YOUR PHYSICIAN
CAREFULLY READ THE PACKAGE INSERT BEFORE USE
FOR FURTHER INFORMATION, DO NOT HESISTATE TO ASK YOUR PHYSICIANS
Manufactured at:
BOSTON VIETNAM PHARMACEUTICAL JOINT STOCK COMPANY
No. 43, Street no. 8, VSIP, Thuan An, Binh Duong
Tel: 06503 769 606 - Fax: 06503 769 601


 


Others


Categories


Selling product

Hightlights